Cowboys Vs. 49ers Spread, Line, Odds, Picks For NFL Playoffs Wild Card Game

The Dallas Cowboys are matching up with the San Francisco 49ers in the Wild Card round of the 2022 NFL playoffs today.

This game features two of the NFC’s marquee franchises going head-to-head with a spot in the Divisional round on the line. Both sides have had infrequent success over the last two decades and have fan bases desperate to see their squad advance through the postseason bracket.

The odds suggest this bout between No. 3-seeded, NFC East-winning Dallas and No. 6 seed San Francisco—one of three NFC West teams to reach the playoffs this year—is the most evenly matched battle of all the Wild Card contests. It also has real potential to be the highest scoring of the six games this weekend, making it one you will not want to miss.

Before taking a deeper dive into this Cowboys-49ers showdown—which includes the start time, TV channel, live stream site, updated odds, betting trends, predictions and more—have a peek at all scores and results from Saturday’s games plus a complete viewing guide for all the remaining Wild Card matchups during the 2022 NFL playoffs.

NFL Playoff Bracket, Results, Schedule


1. Tennessee Titans (BYE)

2. Kansas City Chiefs vs. 7. Pittsburgh Steelers (Sun, Jan. 16 at 8:15 p.m. on NBC)

3. Buffalo Bills vs. 6. New England Patriots (BUF 47 – NE 17)

4. Cincinnati Bengals vs. 5. Las Vegas Raiders (CIN 26 – LV 19)


1. Green Bay Packers (BYE)

2. Tampa Bay Buccaneers vs. 7. Philadelphia Eagles (Sun, Jan. 16 at 1:05 p.m. on Fox)

3. Dallas Cowboys vs. 6. San Francisco 49ers (Sun, Jan. 16 at 4:40 p.m. on CBS)

4. Los Angeles Rams vs. 5. Arizona Cardinals (Mon, Jan. 17 at 8:15 p.m. on ESPN)

Cowboys (12-5) vs. 49ers (10-7) NFC Wild Card Preview

Matchup: NFC No. 3 vs. NFC No. 6

Date: Sunday, Jan. 16, 2022

Start Time: 4:40 p.m. ET

Location: AT&T Stadium, Arlington, TX

Watch: CBS

Live Stream: Paramount+

49ers at Cowboys Wild Card Odds

NFL odds courtesy of FanDuel

Point Spread: Cowboys -3.5

The Cowboys are favored in their return to the playoffs after a two-year hiatus, but the public isn’t buying America’s team in the Wild Card round.

As of Sunday afternoon, 60 percent of the bets and a whopping 80 percent of the handle is on the 49ers to cover the spread.

Despite this lopsided action, the line on this 2022 NFC Wild Card round clash has not moved from its initial mark.

Total: Over-under 51

The total on this game projects a high-scoring outcome, an unsurprising revelation given the Cowboys were the highest-scoring team during the 2021 campaign.

The public is relatively split on this total, with the over only holding a slight edge with 54 percent of the tickets. The handle is heavily skewed in the over’s favor, however, as 88 percent of the money wagered is on that side of the total.

Moneyline: DAL -160, SF +135

The Cowboys are a slight, -160 moneyline favorite in the Wild Card round. Bettors would need to risk $1.60 to win $1 on the NFC East champions winning at home this afternoon.

Those who back the 49ers as a +135 underdog would net $1.35 for each $1 wagered on an upset.

These odds imply a 62.3 percent probability that Dallas advances to the Divisional round and a 42.6 percent probability of San Francisco besting the Cowboys for just the second time since the 2003 season began.  

The percentages add up to over 100 due to the “vig”, a cut the bookmaker takes for facilitating bets.

Dallas vs. San Francisco Betting Trends

  • This will be the 38th all-time meeting between the Cowboys and 49ers. Dallas holds a slight edge in the series, going 19-17-1 since the first matchup in 1960.
  • These foes last met in 2020, a game Dallas won at home by a 41-33 margin as four-point home underdogs.
  • The Cowboys were the best team to bet on in football this year, going 13-4 against the spread (ATS).
  • Dallas wasn’t as strong at home as it was on the road, going 5-3 SU and ATS at AT&T Stadium in 2021. The club was favored in all eight of these home contests.
  • The 49ers covered at a 52.9 percent rate in 2021 (9-8 ATS).
  • San Francisco went 6-3 SU on the road this season, covering in five of those nine contests. The team went 1-1 SU and ATS when getting points away from Santa Clara.
  • The Cowboys have won three in a row and six of their last seven matchups against the 49ers.
  • Dallas hasn’t been a slam-dunk bet in those contests, however, but still holds a 4-2-1 ATS advantage over San Francisco during the last two decades.
  • The total has gone OVER in eight of the last 10 games featuring the Cowboys and 49ers.
  • The visiting squad has won four of the last five games between these teams.
  • San Francisco and Dallas each covered in four of their most recent five games leading up to the 2022 NFL playoffs.

Cowboys vs. 49ers Wild Card Predictions

Spread Pick: Dallas -3.5

Total Pick: Over 51

Prediction: Cowboys 28 – 49ers 24