NFL Playoffs Betting Line, Divisional Picks, Predictions Against The Spread

The Green Bay Packers are hosting the San Francisco 49ers tonight in the first Divisional round matchup on the NFC side of the 2022 NFL playoff bracket.

The Packers had the Wild Card round off after earning the top record in the conference, getting an extra week to rest up and prepare for their postseason run. The 49ers upset the Dallas Cowboys on the road last weekend, but now have an even taller task in front of them to reach the NFC Championship Game.

Green Bay has been installed as 5.5-point chalk for this matchup, making the squad the largest favorite on the board in the Divisional Round. The Pack have the advantage of playing at Lambeau Field this evening, hosting the game at a venue in which they are 23-6 all-time in the postseason.

It projects to be a thrilling matchup, one showcasing some of the league’s most storied teams with their respective seasons on the line. They most recently met in the postseason during the 2020 NFC Championship Game, a contest the Niners won to reach the Super Bowl.

Get ready for the next showdown by checking out a full preview below, including the start time, viewing information and updated odds for not only the Packers-49ers contest, but every game on the 2022 NFL playoff schedule this weekend.

Divisional Round Viewing Guide

^{Matchup (Spread, Total), Time (TV, Live Stream)}

Saturday, Jan. 22

Bengals at Titans (-3.5, o/u 47.5), 4:30 p.m. ET (CBS, Paramount+).

49ers at Packers (-5.5, o/u 47), 8:15 p.m. ET (Fox, Fox Sports GO)

Sunday, Jan. 23

Rams at Buccaneers (-2.5, o/u 48), 3:05 p.m. ET (NBC, NBC Sports Live)

Bills at Chiefs (KC -2, o/u 54), 6:30 p.m. ET (CBS, Paramount+)

Packers (13-4) vs. 49ers (10-7) Divisional Preview

Matchup: NFC No. 1 vs. No. 6

Date: Saturday, Jan. 22, 2022

Start Time: 8:15 p.m. ET

Location: Lambeau Field, Green Bay, WI

Watch: Fox

Live Stream: Fox Sports Go

49ers at Packers Odds

NFL odds courtesy of FanDuel

Point Spread: Packers -5.5

The Packers are laying 5.5 points in the Divisional round, a spread that has moved a half-point in Green Bay’s direction since first going up on the board.

While most public bettors are taking are taking the home side—evidenced by 58 percent of all bets on the Pack’s side—the 49ers are getting plenty of interest from bigger backers.

As of Saturday afternoon, nearly two-thirds (65 percent) of the money wagered against the spread is on San Francisco.

Total: Over-under 47 points

The total on the Packers-49ers game is the lowest of the 2022 NFL playoffs’ four Divisional round matchups. It opened at 47.5 points and has since been bet down a half-point.

Much of the public is rooting for a high-scoring affair, as 60 percent of tickets are on the over. The over is also responsible for more of the handle, but has only a 51 percent advantage there.

Moneyline: GB -235, SF +195

The Packers are sizable favorites to reach the NFC Championship Game for the third consecutive year. Bettors would need to risk $2.35 to win $1 on the team winning by any margin in the Divisional round.

Those believing the 49ers will be victorious this evening will net $1.95 for each $1 staked.

These moneyline odds imply a 70.2 percent probability that Green Bay outright wins on Saturday. San Francisco has a 33.9 percent implied probability of pulling the upset. These percentages eclipse 100 percent due to the “vig”, a cut a sportsbook takes for facilitating bets.

Divisional Round Betting Trends: Packers vs. 49ers

• This will be the 72^nd all-time meeting between the 49ers and Packers, a longstanding rivalry that dates to their first matchup in 1950. Green Bay holds a 38-32-1 all-time advantage in the series.
• San Francisco and Green Bay have split their eight head-to-head postseason contests, winning four apiece.
• The Packers have gotten the better of the Niners in four of the last six matchups, but each team covered in three of those games.
• Green Bay has won and covered in each of the last two games between these clubs.
• The Packers were the second-best team to blindly bet during the 2021 season, with a 12-5 against the spread (ATS) record that trailed only the 13-4 ATS Dallas Cowboys.
• The 49ers were slightly profitable this year, going 9-8 ATS.

• Green Bay was the best home team in football this year, winning all eight games and beating the number in seven those contests at Lambeau Field. The Packers went 7-0 SU and 6-1 ATS as a home favorite.
• San Francisco traveled well this year, winning six of their nine road games and covered slightly more often than at 5-4 ATS. The club finished with a 1-1 SU and ATS record as a road ‘dog in 2021.
• The Niners are one of the hotter teams heading into the second round of the 2022 NFL playoffs, winning and covering in five of their last six games.
• The Packers also won five of their last six, but only covered in three of those contests.
• The total has gone OVER in each of the last three and four of the last five games involving these teams.

NFL Playoff Predictions: Packers vs. 49ers

Spread Pick: Packers -5.5

Total Pick: Over 47

Prediction: Packers 28 – 49ers 21