INGLEWOOD, CALIFORNIA – DECEMBER 27: C.J. Stroud #7 celebrates a touchdown pass with Jake Andrews #60 of the Houston Texans during the first quarter against the Los Angeles Chargers at SoFi Stadium on December 27, 2025 in Inglewood, California. (Photo by Ronald Martinez/Getty Images)
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The NFL Divisional playoffs kick off this weekend with four games in two days.
After Sunday night, the NFL will be down to its Final Four with the AFC and NFC Championship games set for Jan. 25 and Super Bowl LX set for Feb. 8 at Levi’s Stadium in Santa Clara, Calif.
Who are the betting favorites heading into this weekend and what’s the latest skinny?
Here’s a breakdown, per betting site bookmaker.eu
Saturday
Bills at Broncos, 4:30 p.m. EST
Line: Broncos – 1
Bills: CB Maxwell Hairston (ankle): OUT, S Jordan Poyer (hamstring): OUT, WR Tyrell Shavers (knee): OUT, LB Terrel Bernard (calf): questionable, S Damar Hamlin (pectoral): questionable, RB Ty Johnson (ankle): questionable, DT Ed Oliver (biceps): questionable, WR Curtis Samuel (elbow): questionable
Broncos: TE Lucas Krull (foot): OUT, LB Drew Sanders (ankle): OUT
What to know: Patrick Mahomes, Lamar Jackson and Joe Burrow aren’t in the playoffs, so is this finally the year Josh Allen leads the Bills to the Super Bowl? He’ll have to go into Denver and lead his team over Bo Nix and the top-seeded Broncos to have a chance. “I think the [Denver] defense will play well, but they’re going to have to score in the mid-20s to beat Josh Allen,” ESPN’s Booger McFarland said on air. And if Bo Nix can do it and he can play turnover-free football, they’ll win. If Bo Nix can’t do it, then Superman [Allen] along with [running back] James Cook, they’ll come into Denver and they’ll get the win.”
49ers at Seahawks, 8 p.m. EST
Line: Seahawks -7
49ers: S Ji’Ayir Brown (hamstring): OUT, LB Fred Warner (ankle): OUT, WR Jacob Cowing (hamstring): questionable, LB Luke Gifford (quad): questionable, WR Ricky Pearsall (knee): questionable, LB Dee Winters (ankle): questionable
Seahawks: TE Elijah Arroyo (knee): OUT, LB Chazz Surratt (ankle): OUT, T Josh Jones (knee): OUT, QB Sam Darnold (oblique): questionable
What to know: Seahawks QB Sam Darnold was added to the injury report with an oblique issue that makes him “questionable,” but he told reporters Thursday that he still expects to play. Asked what percent of him thinks he might not play, he said, “Very low percentage. Probably closer to zero.”
Sunday
Texans At Patriots, 3 p.m. EST
Line: Patriots -3
Texans: WR Nico Collins (concussion, trending doubtful); OT Trent Brown (ankle)
Patriots: Morgan Moses (knee), Thayer Munford Jr. (knee)
What to know: The Texans led the league in total yards allowed (around 277 per game) and were often No. 1 overall in defense. The Patriots, meantime, are starting two rookie offensive linemen in Will Campbell and Jared Wilson. “They gotta block the Houston Texans,” McFarland said, “so to me that is a mismatch on the offensive line for the Patriots and the defensive line for the Texans.”
Rams At Bears, 6:30 p.m. EST
Line: Rams -4
Rams: TE Terrance Ferguson (hamstring)
Bears: CB Nick McCloud (groin): OUT, WRs DJ Moore (knee) and Rome Odunze (foot) limited
What to know: Game-time temperature is expected to be 21 degrees with a wind chill of 20-25 mph. Rams QB Matthew Stafford sustained a sprained right index finger on his throwing hand during the team’s playoff win over the Panthers on January 11, hitting it backward on a defender’s forearm. So something to watch for is whether the cold weather could aggravate the injury.